Verapamil reduced just the norepinephrine or urotensin II induced contraction within the existence of extracellular Ca2+, with little if any modify during the contraction in Ca2+-free buffer. The urotensin I induced leisure reaction in aortic strips contracted by forty mM KCl was Increased by pretreatment with papaverine or forskolin. Pretreatment with dibutyryl cAMP did not substantially alter the action of urotensin I. The existence or absence of endothelial cells did not change the reaction to urotensin I. These results advise that urotensin I antagonizes the action and (or) mobilization of extracellular and intracellular Ca2+.

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